2004 427:843–8.ĭeinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA, et al. Sortilin is essential for proNGF-induced neuronal cell death. Nykjaer A, Lee R, Teng KK, Jansen P, Madsen P, Nielsen MS, et al. The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy. Young WS, Li J, Wersinger SR, Palkovits M. Rediscovering area CA2: unique properties and functions. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics. Meira T, Leroy F, Buss EW, Oliva A, Park J, Siegelbaum SA. Targeted activation of the hippocampal CA2 area strongly enhances social memory. Smith AS, Williams Avram SK, Cymerblit-Sabba A, Song J, Young WS. The hippocampal CA2 region is essential for social memory. Thus, our findings provide a new mechanism for social memory formation, through regulating synaptic receptor trafficking in pyramidal neurons by SorCS2. Mutations in sorCS2 have been associated with bipolar disease, schizophrenia, and attention deficient-hyperactivity disorder, and abnormalities in social memory are core components of these neuropsychiatric conditions. To specifically test the role of SorCS2 in behavior, we generated a novel SorCS2-deficient mouse, and identify a significant social memory deficit, with no change in sociability, olfaction, anxiety, or several hippocampal-dependent behaviors. In addition, SorCS2 regulates dendritic spine density in CA2 neurons where SorCS2 expression is enriched, but not in dorsal CA1 neurons, which normally express very low levels of this protein. We have discovered that SorCS2 is a selective regulator of NMDA receptor surface trafficking in hippocampal neurons, without altering AMPA receptor trafficking. SorCS2 specifically localizes to the postsynaptic density and endosomes within dendritic spines of CA2 neurons. Here, we document that SorCS2, a member of the family of the Vps10 family of sorting receptors, is highly expressed in pyramidal neurons of CA2, as well as ventral CA1, a circuit implicated in social memory. doi:10.3389/ memory processing requires functional CA2 neurons, however the specific mechanisms that regulate their activity are poorly understood. Do false memories look real? Evidence that people struggle to identify rich false memories of committing crime and other emotional events. Need for cognition and discrepancy detection in the misinformation effect. Reducing the misinformation effect through initial testing: Take two tests and recall me in the morning?. Inducing resistance to the misinformation effect by means of reinforced self-affirmation: The importance of positive feedback. Memory for flip-flopping: detection and recollection of political contradictions. In: Learning and Memory: A Comprehensive Reference. Planting misinformation in the human mind: a 30-year investigation of the malleability of memory. Whatever gave you that idea? False memories following equivalence training: a behavioral account of the misinformation effect. Leading questions and the eyewitness report. In these cases, the misleading information is much easier to retrieve, effectively blocking the retrieval of the original, correct information.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |